Аннотация:The stress response in epithelium is particularly important because epithelial tissues in many cases serve as a barrier between the internal milieu and sometime hostile external environment and experience more severe insults compared to other tissues. Wip1 phosphatase as a regulator of several stress signaling pathways such as MAP kinases, DNA damage response, is involved in homeostasis of epithelial tissues and implicated in several pathologies (for review, see [1]). Previously, we have shown that Wip1 plays a critical role in regulation of stress response and tumorigenesis in intestinal epithelium [2,3].