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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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1-tert-Butyloxycarbonyl-1-methylhydrazineстатья
- Авторы: Karchava Alexander V., Melkonyan Ferdinand S.
- Сборник: e-EROS Encyclopedia of Reagents for Organic Synthesis
- Год издания: 2010
- Издательство: Wiley & Sons
- Местоположение издательства: Chichester, Sussex, UK, England
- DOI: 10.1002/047084289X.rn01194
- Аннотация: [21075-83-221075-83-2] C6H14N2O2 (MW 146.19) InChI = 1S/C6H14N2O2/c1-6(2,3)10-5(9)8(4)7/h7H2,1-4H3 InChIKey = IHMQNZFRFVYNDS-UHFFFAOYSA-N (starting material for the regioselective preparation of substituted hydrazines and heterocyclic compounds)Alternate Names: 1-Boc-1-methylhydrazine; tert-butyl azaalanine; tert-butyl 1- methylhydrazinecarboxylate.Physical Data: d25 0.985 g cm−3; nD20 1.436, bp 65–67 °C/10 mmHg.Solubility: soluble in most organic solvents.Form Supplied in: as a liquid, available from several suppliers.Analysis of Reagent Purity: by H1 NMR.Preparative Methods: the reagent is easily prepared by the reaction of di-tert-butyldicarbonate and methylhydrazine in CDCl3, ethanol, methanol, or THF under cooling. In all cases, the product was obtained as a colorless or yellow liquid in high yield (80–90%) and sufficient purity (by NMR2) and was used without further purification. This reagent has also been obtained starting from N-Boc-aminophthalimide by subsequent methylation under the Mitsunobu conditions and dephthaloylation by MeNHNH2 in 63% overall yield. Although 1-Boc-1-methylhydrazine is easily decomposed by hydrochloric acid, a crystalline hydrochloride (mp 124–125 °C) could be isolated by carefully controlled addition of a solution of HCl in Et2O to a solution of the compound in Et2O and subsequent recrystallization from Et2O–CH2Cl2.Purification: usually used without purification. Distillation at reduced pressure may result in lower yield due to decomposition.Handling, Storage, and Precautions: stable compound, no special handling is required. Harmful if swallowed.
- Добавил в систему: Карчава Александр Вахтангович