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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Development of a standard phantom of the human eye to internal dose assessmentsтезисы доклада
- Авторы: Fotina O.V., Eremenko D.O., Gulyaeva T.V., Platonov S.Yu, Yuminov O.A., Tultaev A.V.
- Сборник: Book of Abstracts of International Nuclear Physics Conference INPC2013 (2-7 June 2013, Firenze, Italy)
- Тезисы
- Год издания: 2013
- Первая страница: AP 015
- Последняя страница: AP 015
- Аннотация: The work is done in a series of studies on the development of α-emitter pharmaceutical "Astatine-211". One of the key objectives of the study is the assessment of radiation exposure to the eye and lens of the eye in relation to the known cases of eye disease in clinical use of the isotope 131I (which is analog to the developed pharmaceutical "Astatine-211") for the thyroid gland treatment. To solve this problem in the environment of GEANT-4 was simulated human anatomy and were evaluated absorbed fractions in the target “eye” from all the organs sources, and the reverse (“eye” as the source organ) for γ-radiation of standard range energies and α-spectrum of 211At with a known activity distribution of the pharmaceutical. Modeling the anatomy is based on the application of standard MIRD phantom model. To go to more accurate estimates of the absorbed dose within the created software ORNL phantom is introduced, which is specific for age and gender. Primary testing of ORNL model for γ-radiation was carried out. The created software allows visualization of particle tracks and anatomy design to prevent inadvertent errors in the initial conditions of the activity distribution of radiopharmaceuticals. As a result of a study two new organs the eye and eye-lens are added in the standard adult-human phantom. Software calculations show that the use of α-emitter radiopharmaceutical "Astatine-211" reduces the radiation exposure on the eyes and eye-lens by few orders of magnitude in comparison with the use of I-131 with the same therapeutic doses in the irradiated organ - the thyroid gland
- Добавил в систему: Еременко Дмитрий Олегович