Alternative Variants of the Human Hydin Are Novel Cancer-Associated Antigens Recognized by Adaptive Immunity

Laske, K.; Shebzukhov, Y.; Grosse-Hovest, L.; Kuprash, D.; Khlgatian, S.; Koroleva, E.; Sazykin, A.; Belousov, P.; Stevanovic, S.; Penkov, D.; Vass, V.; Walter, S.; Eisel, D.; D, S.B.; A, N.S.; Ramensee, H.; Gouttefangeas, C.

Авторы: Karoline Laske, Yury Shebzukhov, Ludger Grosse-Hovest, Dmitry Kuprash, Svetlana Khlgatian, Ekaterina Koroleva, Alexey Sazykin, Pavel Belousov, Stefan Stevanovic, Dmitry Penkov, Verona Vass, Steffen Walter, David Eisel, Schmid-Horch Barbara D., Nedospasov S.A., Hans-Georg Ramensee, Cecile Gouttefangeas
Журнал: Cancer Immunology Research
Год издания: 2013
DOI: 10.1158/2326-6066.CIR-13-0079
Аннотация: A mutation in the hydin gene has been recently described as one possible mechanism leading to lethal congenital hydrocephalus in mice, and a similar defect is proposed to be involved in an autosomal recessive form of hydrocephalus in human. Here, we report for the first time on the cancer association and immunogenicity of two HYDIN variants in humans. One is a previously described sequence derived from the chromosome 1 gene copy, that is, KIAA1864. The second is encoded by a novel alternative transcript originating from the chromosome 16, which we identified by immunoscreening of a testis-derived cDNA expression library with sera of patients with colorectal cancer, and called MO-TES391. Both variants are targeted by immunoglobulin G antibodies in a significant subset of cancer patients but only rarely in healthy donors. Moreover, we identify HLA-A*0201-restricted sequences derived from MO-TES391 and KIAA1864, which are specifically recognized by human cytotoxic CD8(+) T cells. Taken together, these results suggest frequent and coordinated adaptive immune responses against HYDIN variants in patients with cancer and propose HYDIN as a novel cancer-associated antigen.
Добавил в систему: Сазыкин Алексей Юрьевич

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Alternative Variants of the Human Hydin Are Novel Cancer-Associated Antigens Recognized by Adaptive Immunityстатья

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