|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
THE ROLE OF B-1-LYMPHOCYTES IN ANTITUMOR IMMUNITYIN PATIENTS WITH GASTRIC CANCERстатья
- Авторы: Chulkova S.V., Glukhov E.V., Grivtsova L.Yu, Sholokhova E.N., Tupitsyn N.N.
- Сборник: HÆMATOPOÏESIS IMMUNOLOGY
- Том: 16
- Год издания: 2018
- Место издания: Россия
- Первая страница: 161
- Последняя страница: 165
- Аннотация: B1-lymphocytes are a relatively small group of B-cells which foundin humans and mice, the most phylogenetically oldest branch of antibody-producing cells. Throughout life the B1-lymphocyte pool is maintained by the activityof progenitor cells through their very slow proliferation. B1-cells are characterizedby an “activated phenotype”, which is manifested in the expression on their surfaceof costimulatory molecules CD80 and CD86. There are 2 subpopulations of B1-cells:B1a and B1b. B1b are similar to B1a, but they are characterized by the absence of CD5expression. The antibodies produced by B1-lymphocytes are almost exclusively IgM.The response of B1-cells is mainly thymic independent. IgM plays an important rolein the induction of apoptosis of tumor cells. Approximately half of serum IgM is secreted by B1-cells. A small number of B1-lymphocytes, mainly cells secreting antibodies, are detected in the spleen, where they account for up to 5 % of the numberof B-cells. Splenectomy for the purpose of adequate lymphodissection in stomachcancer causes pronounced and long-term dysfunction of the various parts of the immune system. Immunity disorders in patients after splenectomy primarily affect theB-cell immune response, including thymus-independent antigens of the second type,which is provided by the population of B1a-lymphocytes.
- Добавил в систему: Чулкова Светлана Васильевна