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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Implantable fiber-optic interface for parallel multisite long-term optical dynamic brain interrogation in freely moving miceстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Doronina-Amitonova L.V., Fedotov I.V., Ivashkina O.I., Zots M.A., Fedotov A.B., Anokhin K.V., Zheltikov A.M.
- Журнал: Scientific reports
- Том: 3
- Номер: Article number 3265
- Год издания: 2013
- Издательство: Nature Publishing Group
- Местоположение издательства: United Kingdom
- DOI: 10.1038/srep03265
- Аннотация: Seeing the big picture of functional responses within large neural networks in a freely functioning brain is crucial for understanding the cellular mechanisms behind the higher nervous activity, including the most complex brain functions, such as cognition and memory. As a breakthrough toward meeting this challenge, implantable fiber-optic interfaces integrating advanced optogenetic technologies and cutting-edge fiber-optic solutions have been demonstrated, enabling a long-term optogenetic manipulation of neural circuits in freely moving mice. Here, we show that a specifically designed implantable fiber-optic interface provides a powerful tool for parallel long-term optical interrogation of distinctly separate, functionally different sites in the brain of freely moving mice. This interface allows the same groups of neurons lying deeply in the brain of a freely behaving mouse to be reproducibly accessed and optically interrogated over many weeks, providing a long-term dynamic detection of genome activity in response to a broad variety of pharmacological and physiological stimuli.
- Добавил в систему: Федотов Андрей Борисович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | srep03265_Mice.pdf | 3,1 МБ | 2 декабря 2013 [a.b.fedotov] |