Synthesis and chemical properties of adamantylated nucleic bases and related compoundsстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 мая 2015 г.
Аннотация:Data published in 1999 – 2011 on the synthesis and chemical properties of adamantyl-containing nucleic bases and related compounds are reviewed, systematized, and analyzed. Adamantyl-containing heterocyclic compounds, which have received much attention in attempts to create highly effective and selective drugs that were described in previous reviews devoted to heteryladamantanes, occupy a special place in adamantane chemistry. The number of publications devoted to the synthesis and characterization of adamantyl-containing nucleic bases was small and restricted mostly to derivatives containing unsubstituted adamantane. The ability to overcome this limitation was realized only in the last decade. Available data on the biological activity of synthesized compounds indicate good prospects for research in this direction.