|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
Adversary of DNA integrity: a long non-coding RNA stimulates driver oncogenic chromosomal rearrangement in human thyroid cellsстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Eriksonovich Demin Denis, Murashko Matvey Mikhailovich, Uvarova Aksinya Nicolaevna, Stasevich Ekaterina Mikhailovna, Shyrokova Elena Yurievna, Gorlachev Gennady Efimovich, Zaretsky Andrew Rostislavovich, Korneev Kirill Viktorovich, Ustiugova Alina Sergeevna, Tkachenko Elena Andreevna, Kostenko Valentina Vitalevna, Tatosyan Karina Aleksandrovna, Sheetikov Saveliy Andreevich, Spirin Pavel Vladimirovich, Kuprash Dmitry Vladimirovich, Schwartz Anton Markovich
- Журнал: International Journal of Cancer
- Год издания: 2022
- Издательство: John Wiley & Sons Inc.
- Местоположение издательства: United States
- DOI: 10.1002/ijc.34396
- Аннотация: The flurry of publications devoted to the functions of long non-coding RNAs (lncRNAs) published in the last decade leaves no doubt about the exceptional importance of lncRNAs in various areas including tumor biology. Contribution of lncRNAs to the early stages of oncogenesis remains poorly understood. In this study we explored a new role for lncRNAs: stimulation of specific chromosomal rearrangements upon DNA damage. We demonstrated that lncRNA CASTL1 (ENSG00000269945) stimulates the formation of the CCDC6-RET inversion (RET/PTC1) in human thyroid cells subjected to radiation or chemical DNA damage. Facilitation of chromosomal rearrangement requires lncRNA to contain regions complementary to the introns of both CCDC6 and RET genes as deletion of these regions deprives CASTL1 of the ability to stimulate the gene fusion. We found that CASTL1 expression is elevated in tumors with CCDC6-RET fusion which is the most frequent rearrangement in papillary thyroid carcinoma. Our results open a new venue for the studies of early oncogenesis in various tumor types, especially those associated with physical or chemical DNA damage.
- Добавил в систему: Купраш Дмитрий Владимирович