Аннотация:Compression of molecules is a means to control conformations of molecules, to restrict their mobility via perturbation of intermolecular potentials and modify their ionization potentials and electron affinity by violation of atomic orbitals and intra-molecular potentials. Compression induced modification of the vibrational frequencies increases the difference of zero point energies of isotopic molecules, which results to increasing isotope effects; the latter are suggested to use as a tool for measuring molecular compression. By compression of single crystals the reaction trajectories of hydrogen atom transfer were identified. Compression is a means for the key, Life supporting enzymes, ATP synthase and DNA polymerase, to function as the compressing molecular devices; it urges nucleophile reactions of ATP and DNA synthesis to occur overcoming high energy repulse barrier for the reactions of molecules with closed electronic shells. By using nuclear magnetic ions of magnesium, calcium, and zinc, catalyzing enzymatic ATP and DNA synthesis, a new mechanism induced by compression of enzymatic site is discovered. This mechanism strongly, by 3−5 times, suppresses DNA synthesis and even more strongly, by 30−50 times, increases mortality of cancer cells. In this case compression of enzymatic site dehydrates metal ions stimulating electron transfer and switching on the new, highly efficient radical pair mechanism responsible for the killing cancer cells.