|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
Polymer/magnetite carriers functionalized by HER2-DARPin: Avoiding lysosomes during internalization and controlled toxicity of doxorubicin by focused ultrasound induced releaseстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Novoselova M.V., Shramova E.I., Sergeeva O.V., Shcherbinina E.Y., Perevoschikov S.V., Melnikov P., Griaznova O.Yu, Sergeev I.S., Konovalova E.V., Schulga A.A., Proshkina G.M., Zatsepin T.S., Deyev S.M., Gorin D.A.
- Журнал: Nanomedicine
- Том: 47
- Год издания: 2023
- Издательство: Future Medicine Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 102612
- DOI: 10.1016/j.nano.2022.102612
- Аннотация: Nanomedicine has revolutionized the available treatment options during the last decade, but poor selectivity of targeted drug delivery and release is still poses a challenge. In this study, doxorubicin (DOX) and magnetite nanoparticles were encapsulated by freezing-induced loading, coated with polymeric shell bearing two bi-layers of polyarginine/dextran sulphate and finally modified with HER2-specific DARPin proteins. We demonstrated that the enhanced cellular uptake of these nanocarriers predominantly occurs by SKOV-3 (HER2+) cells, in comparison to CHO (HER2−) cells, together with the controlled DOX release using low intensity focused ultrasound (LIFU). In addition, a good ability of DARPin+ capsules to accumulate in the tumor and the possibility of combination therapy with LIFU were demonstrated. A relatively high sensitivity of the obtained nanocarriers to LIFU and their preferential interactions with mitochondria in cancer cells make these carriers promising candidates for cancer treatment, including novel approaches to overcome drug resistance.
- Добавил в систему: Зацепин Тимофей Сергеевич