Аннотация:Long-term effects of vigorous shaking of aqueous solutions of medical drugs upon theproperties of these solutions were discovered more then 200 years ago by the German physicianSamuel Hahnemann. He noticed that very low and extra-low dilutions of drugs manifestedtherapeutic activity only if at each dilution step, they were vigorously succussed. Thistechnique was named “potentization” and preparations obtained using it were called“homeopathic medicines”. Until recently, and to a large extent even now, the attitude towardshomeopathy and homeopathic medicines remained extremely skeptical among most physiciansand specialists in the field of physical-chemical biology. Partially this skepticism is based onthe a priori notion that properties of aqueous solutions must return to their initial equilibriumstate shortly after the termination of the mechanical action. However, during the last decadesthere accumulated a lot of data proving that even moderate mechanical treatment of water andaqueous solutions may change their properties significantly. As far as we know, the firstsystematic research in this area was started by Russian physicists G. Domrachev and D.Selivanovsky and their colleagues in the 1990s. They found that H2O2, accumulates in the waterafter water treatment with audible sound, or in water passed through thin capillaries, after itsеvaporation/condensation, or freezing/thawing. They considered water as a heterogenoussystem containing quazi-polymeric structures besides free water molecules and suggested amechanochemical hypothesis of water splitting into radicals and atoms. The phenomenon ofwater splitting accompanied with H2O2, accumulation was later confirmed by other scientists(S. Ikeda et al., V. Bruskov et al., S. Gudkov et al., I. Shcherbakov and others).Previously we have demonstrated that the addition of minute quantities of H2O2 to weakbicarbonate solutions and even mild shaking of them initiates in them a process accompaniedwith the emergence of self-igniting photon emission. The process may last in activatedsolutions for many months without a decay. This indicates that mechanical treatment ofaqueous systems may convert them into active media due to initiation in them long-lastingred/ox chain processes with reactive oxygen species (ROS) participation. Properties of theseaqueous systems depend upon the composition of initial solutions and the number of dilutionsteps with mechanical agitation at each step. In particular, we compared some physicalchemical properties of hydrated C60 fullerene (HyFn) solutions in a wide range of dilutionsprepared using potentization with equivalent “dilutions” of pure water. Buffering capacity, rateof evaporation, mesoscopic heterogeneity of both HyFn dilutions and of pure water “dilutions”differed significantly from such properties of non-succussed water up to the calculated HyFn“concentrations” 10-31 M. At the same time, the special properties of HyFn dilutions thatdistinguish them from non-succussed water were expressed much more intensely than that ofdilutions of agitated water. These results are consistent with observations of others thatmechanical treatment of water changes its properties for a long time, in particular, due to theinitiation of long-lasting chain reactions in which ROS participate. Besides, the properties ofmechanically treated water systems, even after their extremely high dilution, significantlydepend on the initial composition of the aqueous system subjected to potentization.
