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Functional characteristics of the developing brain after early postnatal neuroimmunization in rats: behavioral analysisстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 августа 2017 г.
- Авторы: Zubova O.B., Oknina N.B.
- Журнал: Neuroscience and Behavioral Physiology
- Том: 19
- Номер: 1
- Год издания: 1989
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- Первая страница: 112
- Последняя страница: 119
- DOI: 10.1007/BF01148406
- Аннотация: Conclusions 1. Changes in the behavior of young rats immunized at an early age with antigenic complexes of the brain of adult animals are identified. The physiological effects of neuroimmunization with antigenic complexes of the hippocampus are more constant and more intensely expressed as compared with those of the neocortex. 2. A pronounced reduction in adaptive capabilities is observed in animals immunized with an antigenic complex of the hippocampus. This is manifested in an attentuation of the capacity to reorganize behavior in the presence of change in the conditions of the experiments, and is manifested as well in a decrease in the proportion of animals actively removing themselves from unfavorable factors (14–17 days of age; Y-maze); in an attentuation of all manifestations of orienting behavior in the open field at the age of three weeks; and in the reduction in the indices of training to active avoidance at the age of 35–42 days. 3. In immunized animals, the intensification of immunoactivity in relation to the antigens of nervous tissue has been demonstrated (according to the data of immunological analysis). 4. The identified changes in the functional characteristics of the activity of the brain of developing animals, immunized with hippocampal antigens, are caused by a disturbance in the neuroimmune interaction at the early stages of postnatal development.
- Добавил в систему: Панкова Наталия Борисовна