Функциональные характеристики развивающегося мозга после ранней постнатальной иммунизации: анализ поведениястатья
Статья опубликована в журнале из списка RSCI Web of Science
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Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 марта 2017 г.
Аннотация:In experiment on Wistar line young rats immunized in the early postnatal period with antigenic complex of the nervous tissue of the hippocampus or the neocortex of an adult rat, the influence was studied of the change of immunoreactivity to antigenic complex of these structures on the functional brain development. Experimental animals were immunized twice in the age 5 and 12 days or daily in the first 7 days of life. Studies of the behaviour of experimental and control anomals in various situations, beginning from the two-week age, revealed expressed distinction in the behaviour of animals, immunized by the hippocampus antigens: reduction of the capability to change the behaviour in chenged experimental conditions (two-weeks age), and also a deficit of orienting (three weeks age) and conditioned (six weeks age) activities. A raised level was found of anticerebral antibodies in 1.5-months animals immunized in the early age. Suggestion is expressed about the significance of neuroimmune interaction in the mechanisms of the functional brain development.