Взаимосвязь между метаболическими сдвигами и функциональной активностью сердечно-сосудистой системы при действии токсических элементов и коррекции элементного статусастатья

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[1] Взаимосвязь между метаболическими сдвигами и функциональной активностью сердечно-сосудистой системы при действии токсических элементов и коррекции элементного статуса / И. Б. Алчинова, Н. Б. Панкова, Е. Н. Архипова и др. // Микроэлементы в медицине. — 2008. — Т. 9, № 1-2. — С. 5–6. The combined use of standard trace element assay protocol (ICP-AES, ICP-MS) in individuals with different content of some chemical elements (Hg, As, Mn, etc.) and laser correlation spectroscopy (LCS) of blood serum, urine, and oropharyngeal washout fluid (OPWF) was provided. The relative content of particles of different size, measured by LCS, characterizes the direction of metabolic shifts in the organism. It was found that the incidence of some metabolic shifts correlated with the content of the test elements. In particular, the lower was arsenic concentration in urine samples, the higher was the con-tribution of large particles into light scatteringmOPWFsarnples(r=-0.79,p<0.05); significant correlations between the shifts in the blood serum and metal concentration in the urine were found: Hg (r=0.50, p<0.05) and As (r=0.82, p<0.05). So, the data produced by the above two methods were in good correlation. The heart rate, peripheral arterial blood pressure, and respira-tion parameters were simultaneously recorded in adult subjects before and after course of elemental status correction. Analysis of the relationship between cardiovascular system parameters and the contribution of certain particles into light scattering revealed a correlation between the VLF zone of HR spectrum and second zone of LC-spectra (r = 0.464, p = 0.007). The combination of elemental analysis of biological fluids/hair, LCS and spiroarteriocardiorhythmography can help to determine risk groups for the development of pathologies under conditions of ecological, industrial and nutritional hazard.

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