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Features of the subpopulation composition of peripheral blood B lymphocytes in patients with gastric cancerтезисы доклада
- Авторы: Чулкова С.В., Колбацкая О.П., Тупицын Н.Н., Шолохова Е.Н., Гривцова Л.Ю.
- Сборник: Материалы V Петербургского международного онкологического форума "Белые ночи 2019"
- Тезисы
- Год издания: 2019
- Место издания: АННМО "Вопросы онкологии" Санкт-Петербург
- Первая страница: 355
- Последняя страница: 355
- Аннотация: The histological unit, which is the site of B2cell concentration, is the lymphoid follicle. These cells make up the vast majority of circulating B lymphocytes. B2 cells undergo selection in the bone marrow and are involved in the formation of an adaptive humoral immune response to thymus-dependent antigens. Thus in patients with gastric cancer an interruption of the immunological repertoire of B2 cells was established: the presence of a pronounced proportion of CD21+ B cells with weak expression, a significant number of CD23+ cells, cases of clonal B cells. In most of the studied samples, B cells were polyclonal with a predominance of Ig-κ. When implementing the thymus-dependent pathway of the immune response in such patients, there will be an interruption of antibody production and weakening of antitumor immunity.
- Добавил в систему: Чулкова Светлана Васильевна