Сomplex Relationships between HIV-1 Integrase and Its  Cellular Partners

Авторы: Anna Rozina, Anisenko Andrey, Kikhai Tatiana, Silkina Maria, Gottikh Marina
Журнал: International Journal of Molecular Sciences
Том: 23
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 12341
DOI: 10.3390/ijms232012341
Аннотация: RNA viruses, in pursuit of genome miniaturization, tend to employ cellular proteins to facilitate their replication. HIV-1, one of the most well-studied retroviruses, is not an exception. There is numerous evidence that the exploitation of cellular machinery relies on nucleic acid-protein and protein-protein interactions. Apart from Vpr, Vif, and Nef proteins that are known to regulate cellular functioning via interaction with cell components, another viral protein, integrase, ap-pears to be crucial for proper virus-cell dialog at different stages of the viral life cycle. The goal of this review is to summarize and systematize existing data on known cellular partners of HIV-1 integrase and their role in the HIV-1 life cycle
Добавил в систему: Готтих Марина Борисовна

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