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Cyclodextrins and their polymers affect the lipid membrane permeability and increase levofloxacin's antibacterial activity in vitroстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Skuredina Anna A., Tychinina Anastasia S., Le-Deygen Irina M., Golyshev Sergey A., Kopnova Tatiana Yu, Le Nickolay T., Belogurova Natalya G., Kudryashova Elena V.
- Журнал: Polymers
- Том: 14
- Номер: 20
- Год издания: 2022
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 4352
- DOI: 10.3390/polym14214476
- Аннотация: Cyclodextrins (CDs) are very promising drug carriers that are used in medicine. We chose CDs with different substituent (polar/apolar, charged/neutral) to obtain polymers (CDpols) with different properties. CDpols are urethanes with the average Mw ~120 kDa, they form nanoparticles 100-150 nm in diameter with variable ζ-potential. We studied CD' and CDpols' interaction with model (liposomal) and bacterial membranes. Both types of CD carriers cause the increase of the liposomal membrane permeability, and for polymers this effect is almost 2 times stronger. The formation of CD/CDpols complexes with levofloxacin (LV) enhances LV's antibacterial action 2 times in vitro on 5 bacterial strain. The most pronounced effect was determined for LV-CD complexes. LV-CDs and LV-CDpols adsorb on bacteria, and cells' morphology influence this process dramatically. According to TEM studies «rough» surface and proteinaceous fimbria of gram-negative E . coli faciliate adsorption of CD particles, whereas smooth surface of gram-positive bacteria impedes it. In comparison with LV-CDs LV-CDpols are adsorbed 15% more effectively by E.coli, 2.3 times better by lactobacilli and 5 times better in case of B. subtilis. CDs' and CDpols' are not toxic for bacterial cells, but may cause mild defects that, in addition to LV-CD carrier adsorbtion, improve LV's antibacterial properties.
- Добавил в систему: Ле-Дейген Ирина Михайловна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | polymers-1922048.pdf | 1,8 МБ | 15 октября 2022 [i.m.deygen] | |
| 2. | Acceptance-Certificate-polymers-1922048.pdf | Acceptance-Certificate-polymers-1922048.pdf | 183,9 КБ | 15 октября 2022 [i.m.deygen] |