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Grading cartilage damage with diffuse reflectance spectroscopy: optical markers and mechanical propertiesстатья Исследовательская статья
- Авторы: Rovnyagina Nataliya R., Budylin Gleb S., Dyakonov Pavel V., Efremov Yuri M., Lipina Marina M., Goncharuk Yuliya R., Murdalov Emirkhan E., Pogosyan David A., Davydov Denis A., Korneev Alexander A., Serejnikova Natalia B., Mikaelyan Karen A., Evlashin Stanislav A., Lazarev Vladimir A., Lychagin Alexey V., Timashev Peter S., Shirshin Evgeny A.
- Журнал: Journal of Biophotonics
- Год издания: 2022
- Издательство: Wiley - VCH Verlag GmbH & CO. KGaA
- Местоположение издательства: Germany
- DOI: 10.1002/jbio.202200149
- Аннотация: Osteoarthritis (OA) is one of the most common joint diseases worldwide. Unfortunately, clinical methods lack the ability to detect OA in the early stages. Timely detection of the knee joint degradation at the level of tissue changes can prevent its progressive damage. Here, diffuse reflectance spectroscopy (DRS) in the NIR range was used to obtain optical markers of the cartilage damage grades and to assess its mechanical properties. It was observed that the water content obtained by DRS strongly correlates with the cartilage thickness (R = 0.82) and viscoelastic relaxation time (R = 0.7). Moreover, the spectral parameters, including water content (OH-band), protein content (CH-band) and scattering parameters allowed for discrimination between the cartilage damage grades (10-4 < p ≤ 10-3). The developed approach may become a valuable addition to arthroscopy, helping to identify lesions at the microscopic level in the early stages of OA and complement the surgical analysis.
- Добавил в систему: Ширшин Евгений Александрович