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Intrinsic disorder in the BK channel and its interactomeстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Peng Z., Sakai Y., Kurgan L., Sokolowski B., Uversky V.
- Журнал: PLoS ONE
- Том: 9
- Номер: 4
- Год издания: 2014
- Издательство: Public Library of Science
- Местоположение издательства: United States
- Первая страница: e94331
- Аннотация: 60% of the disordered segments in BKAPs are short IDRs that range in length from 4 to 30 residues. Both α and γ subunits showed various amounts of disorder as did hub proteins of the BK interactome. Our analyses suggest that intrinsic disorder is important for the function of BK and its BKAPs. Long IDRs in BK are engaged in protein-protein and protein-ligand interactions, contain multiple post-translational modification sites, and are subjected to alternative splicing. The disordered structure of BK and its BKAPs suggests one of the underlying mechanisms of their interaction.
- Добавил в систему: Уверский Владимир Николаевич