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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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SYNTHESIS, STRUCTURE AND ANTITUMOR ACTIVITY OF THE BINUCLEAR TETRANITROSYL IRON COMPLEX WITH 2-MERCAPTOBENZTHIAZOLE–THE NITRIC OXIDE DONOR (NO)статья
- Авторы: Rudneva T.N., Shilov G.V., Sanina N.A., Aldoshin S.M., Zhukova O.S., Chikileva I.O., Kisilevskii M.V.
- Журнал: Journal of Coordination Chemistry
- Том: 72
- Номер: 5-7
- Год издания: 2019
- Издательство: Gordon and Breach Science Publishers
- Местоположение издательства: Switzerland
- Первая страница: 972
- Последняя страница: 986
- Аннотация: Single-crystals of binuclear neutral sulfur-nitrosyl iron complex with 2-mercaptobenzthiazole ligand [Fe2(С7н4NS2)2(NO)4] (BTz) have been obtained. From X-ray data, BTz has a centrosymmetric dimeric structure, with the iron atoms being linked through the µ-N-C-S bridge. As follows from mass-spectra of the BTz gas phase, the complex is stable in the crystalline state under normal conditions (ambient temperature and standard humidity) and releases nitric oxide upon heating. Using amperometry, kinetics of NO release by BTz in 1% dimethyl sulfoxide aqueous solution has been studied: release of NO was shown to occur immediately upon dissolution in protic media. BTz inhibited growth of K562 leukemia and SKOV3 ovarian carcinoma cells in vitro and induced apoptosis via activation caspases 3 and 7. Graphical abstract
- Добавил в систему: Жукова Ольга Степановна