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Photophysical properties and in vitro and in vivo photoinduced antitumor activity of cationic salts of meso-tetrakis(N-alkyl-3-pyridyl)bacteriochlorinsстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 марта 2017 г.
- Авторы: Yakubovskaya Raisa I., Plotnikova Еkaterina А., Plyutinskaya Anna D., Morozova Natalya B., Chissov Valery I., Makarova Elena A., Dudkin Semen V., Lukyanets Evgeny A., Vorozhtsov Georgy N.
- Журнал: Journal of Photochemistry and Photobiology B: Biology
- Том: 130
- Год издания: 2014
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 109
- Последняя страница: 114
- DOI: 10.1016/j.jphotobiol.2013.10.017
- Аннотация: Physico-chemical properties, biodistribution in animal tissues, and PDT efficacy of bacteriochlorin photosensitizers, namely cationic salts of synthetic meso-tetrakis(N-alkyl-3-pyridyl)bacteriochlorins were studied in HEp2 cell line and in the LLC mouse model. The tested compounds showed high stability in the dark and high in vitro phototoxicity against HEp2 cells (the half maximal inhibitory concentration LD50 in the range from 0.34 ± 0.03 to 1.5 ± 0.03 lm). Synthetic bacteriochlorins rapidly accumulate in mouse tumor tissue with tumor-to-normal tissue fluorescence contrast ratios of 2.3–3.3, possess high PDT activity against LLC cells: inhibition of tumor growth, TGI 85.8–100%, increase in life span, ILS 105.7–129.2%, response rate, RR 50–100%. The highest PDT efficacy was found for meso-tetrakis[1-(40-bromobutyl)-3-pyridyl]bacteriochlorin tetrabromide (IC50 0.34 ± 0.03 lm in vitro, TGI and RR 100% in vivo).
- Добавил в систему: Дудкин Семён Валентинович