Аннотация:Our findings established the best GRS model, which simultaneouslyassessed genetic and environmental factors and successfully predicted an increaseddepression level in the testing sample of the similar-age individuals from the samegeographic region of Russia. Notably, the GRS model confirmed the involvement ofgenes encoding for arginine vasopressin receptors, hsa-miR-135a2 together with itstarget MRAS in individual variance in depression-related traits. In addition, the dataobtained confirmed a significant effect of parental style of rearing and income level onindividual differences in depression-related traits.