Fabrication and characterization of a magnetic biocomposite of magnetite nanoparticles and reduced graphene oxide for biomedical applications

Mukhortova, Y.R.; Pryadko, A.S.; Chernozem, R.V.; Pariy, I.O.; Akoulina, E.A.; Demianova, I.V.; Zharkova, I.I.; Ivanov, Y.F.; Wagner, D.V.; Bonartsev, A.P.; Surmenev, R.A.; Surmeneva, M.A.

Авторы: Mukhortova Yulia R., Pryadko Artyom S., Chernozem Roman V., Pariy Igor O., Akoulina Elizaveta A., Demianova Irina V., Zharkova Irina I., Ivanov Yurii F., Wagner Dmitriy V., Bonartsev Anton P., Surmenev Roman A., Surmeneva Maria A.
Журнал: Nano-Structures & Nano-Objects
Том: 29
Год издания: 2022
Издательство: Elsevier B.V.
Местоположение издательства: Netherlands
Номер статьи: 100843
DOI: 10.1016/j.nanoso.2022.100843
Аннотация: Functionalization of magnetite (Fe3O4) nanoparticles with reduced graphene oxide (rGO) with thepreserved magnetic properties of the former presents great potential for applying the Fe3O4/rGObiocomposite in various biomedical applications, such as magnetic resonance imaging, as a therapeuticcomponent in initiating tumour cell death in magnetic and photon ablation therapy, andas an effective carrier for drug delivery. In this study, magnetite nanoparticles (MNPs) with a highsaturation magnetization were synthesized by co-precipitation under various conditions, followed bycovalent functionalization with citric acid (CA) and subsequent attachment to rGO sheets by physicaladsorption. Extensive characterization revealed increasing phase purity with a subsequent decreasein the crystallite size and average size of the MNPs synthesized in an inert atmosphere compared toambient conditions. Meanwhile, further functionalization of the MNPs with CA by covalent bindingdoes not affect the MNP structure and size, but decreases their agglomeration. To study the magneticproperties of the MNPs and the Fe3O4/rGO composite, magnetization curves were obtained with avibrating sample magnetometer at a pulsed magnetic field of up to 6.5 kOe. The largest values ofsaturation magnetization are revealed for the samples synthesized without the addition of CA in aninert atmosphere (σs = 80.27 emu/g). The addition of CA to the synthesized MNPs and Fe3O4/rGOcomposites reduced agglomeration, with σs values in the range from 64.10 to 60.97 emu/g. In vitrobiological experiments revealed the MNP concentrations that did not cause any toxic effects on cellsfor use as magnetic fillers to investigate the strain-mediated effects of hybrid polymer composites oncellular behaviour due to external magnetic field exposure in the next stages of research.
Добавил в систему: Бонарцев Антон Павлович

	ИСТИНА	Войти в систему Регистрация
	Интеллектуальная Система Тематического Исследования НАукометрических данных
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

Интеллектуальная Система Тематического Исследования НАукометрических данных

Fabrication and characterization of a magnetic biocomposite of magnetite nanoparticles and reduced graphene oxide for biomedical applicationsстатья Исследовательская статья

Прикрепленные файлы