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Expanded in vivo studying of antineoplastic properties of amino-acid derivatives of the indolocarbazoleтезисы доклада
- Авторы: Golubeva I.S., Goryunova O.V.
- Сборник: Abstract book. MedChem Russia 2019
- Серия: 4th Russian Conference on Medicinal Chemistry with international participants. MedChem Russia 2019
- Тезисы
- Год издания: 2019
- Место издания: Ural Branch of the Russian Academy of Sciences Екатеринбург
- Первая страница: 345
- Аннотация: Introduction. Introduction to the molecule of the active metabolites (amino acids) affects the physico-chemical and Pro-properties of derivatives of indolocarbazoles. On computers using the predicted probability antitumor activity of these compounds, with low probability of their cytotoxic activity in vitro [1]. Based on these data, conducted a study of 5 compounds in vivo [2]. Objective. Assessment of amino-acid derivates of glycosides of indolocarbazole as potential antitumor medications. Materials and methods. Research antitumor activity of amino-acid derivates of glycosides of indolocarbazol was done using tumorous models of murine - cervical cancer CC-5, epidermoid carcinoma Lewis (LLC), breast adenocarcinoma Ca755, melanoma B16. Sister compounds were injected to mice abdominally five-time, daily with interval of 24 hours. Supervision on animals were continued till their death. Antitumor effect of medications was assessed by criteria of tumor growth inhibition, increase in life expectancy of mice comparing to control animals. Results. As a result of comparative assessment of antineoplastic activity of five APGIKs the L-threonine derivative was chosen for further study. Conclusion. The expanded research in vivo of antineoplastic properties of the selected L-threonine APGIK- derivative is supposed.
- Добавил в систему: Пугачева Ружена Борисовна