Mimicking the liver function in micro-patterned units: Challenges and perspectives in 3D bioprinting

Авторы: Heydari Zahra, Pooyan Paria, Bikmulina Polina, Pozdnyakov Artem, Fomin Victor, Seydi Homeyra, Shpichka Anastasia, Timashev Peter, Vosough Massoud
Журнал: BIOPRINTING
Том: 27
Год издания: 2022
Первая страница: e00208
DOI: 10.1016/j.bprint.2022.e00208
Аннотация: Bioprinting of 3-dimensional (3D) micro-patterned structures could be a promising approach to mimic complex organs in vivo. This technique holds promise for generating micro- and macroscale bioengineered structures in order to produce a platform which will be closest to the original tissues. However, there are many challenges regarding liver tissue engineering, due to the high vascularization of the liver tissue, problems with culturing hepatocytes, and the complex microenvironment of the liver. Here, the current challenges in the bioprinting technique for the liver tissue and their potential solutions are discussed. The most suitable cell types, different bioprinters, and various hydrogels are described.
Добавил в систему: Тимашев Петр Сергеевич

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