Strontium Substituted Tricalcium Phosphate Bone Cement: Short and Long-Term Time-Resolved Studies and In Vitro Properties

Rau, J.V.; Fadeeva, I.V.; Forysenkova, A.A.; Davydova, G.A.; Fosca, M.; Filippov, Y.Y.; Antoniac, I.V.; Antoniac, A.; D\textquotesingleArco, A.; Fabrizio, M.D.; Petrarca, M.; Lupi, S.; Bucchianico Massimo, D.D.; Yankova, V.G.; Putlayev, V.I.; Cristea, M.B.

Авторы: Rau Julietta V., Fadeeva Inna V., Forysenkova Anna A., Davydova Galina A., Fosca Marco, Filippov Yaroslav Yu, Antoniac Iulian V., Antoniac Aurora, D\textquotesingleArco Annalisa, Fabrizio Marta Di, Petrarca Massimo, Lupi Stefano, Bucchianico Massimo Di Menno Di, Yankova Viktoriya G., Putlayev Valery I., Cristea Mihai Bogdan
Журнал: ADVANCED MATERIALS INTERFACES
Год издания: 2022
Первая страница: 2200803
DOI: 10.1002/admi.202200803
Аннотация: Due to a significant influence of strontium (Sr) on bone regeneration, Sr substitutedβ-tricalcium phosphate (Sr-TCP) cement is prepared and investigatedby short- and long-term time-resolved techniques. For short-term investigations,energy-dispersive X-ray diffraction, infrared spectroscopy, and, for thefirst time, terahertz time-domain spectroscopy techniques are applied. Forlong-term time-resolved studies, angular dispersive X-ray diffraction, scanningelectron microscopy, mechanical tests, and behavior in Ringer solution arecarried out. After 45 min of the cement setting, the Sr-TCP phase is no longerdetectable. During this time period, an appearance and constant increase ofthe final brushite phase are registered. The compressive strength of the Sr-TCPcement increases from 4.5 MPa after 2 h of setting and reaches maximum at13.3 MPa after 21 d. After cement soaking for 21 d in Ringer solution, apatitefinal product, with an admixture of brushite and TCP phases is detected. Thecytotoxicity aspects of the prepared cement are investigated using NCTC 3T3fibroblast cell line, and the cytocompatibility—by human dental pulp mesenchymalstem cells. The obtained results allow to conclude that the developedSr-TCP cement is promising for biomedical applications for bone tissue.
Добавил в систему: Путляев Валерий Иванович

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Strontium Substituted Tricalcium Phosphate Bone Cement: Short and Long-Term Time-Resolved Studies and In Vitro Propertiesстатья