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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Protein p16 as a marker of dysplastic and neoplastic alterations in cervical epithelial cellsстатья
- Авторы: Volgareva G., Zavlishina L., Andreeva Y., Frank G., Krutkova E., Golovna D., Bliev A., Spitkovsky D., Ermlova V., Kissljov F.
- Журнал: BMC Cancer
- Том: 31
- Номер: 4
- Год издания: 2004
- Издательство: BioMed Central
- Местоположение издательства: London
- Первая страница: 58
- DOI: 10.1186/1471-2407-4-58.
- Аннотация: Cervical carcinomas are second most frequent type of women cancer. Success in diagnostics of this disease is due to the use of Pap-test (cytological smear analysis). However Pap-test gives significant portion of both false-positive and false-negative conclusions. Amendments of the diagnostic procedure are desirable. Aetiological role of papillomaviruses in cervical cancer is established while the role of cellular gene alterations in the course of tumor progression is less clear. Several research groups including us have recently named the protein p16INK4a as a possible diagnostic marker of cervical cancer. To evaluate whether the specificity of p16INK4a expression in dysplastic and neoplastic cervical epithelium is sufficient for such application we undertook a broader immunochistochemical registration of this protein with a highly p16INK4a-specific monoclonal antibody.
- Добавил в систему: Волгарева Галина Михайловна