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Antitumor effectiveness of combination therapy with platinum and hybrid organotin compound on the Lewis epidermoid carcinoma model with metronomic administrationстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Kotieva I.M., Dodokhova M.A., Safronenko A.V., Alkhuseyn-Kulyaginova M.S., Milaeva E.R., Nikitin E.A., Shpakovsky D.B., Kotieva E.М., Kotieva V.М., Starostin S.I.
- Журнал: Journal of Clinical Oncology
- Том: 40
- Номер: 16 suppl.
- Год издания: 2022
- Издательство: American Society of Clinical Oncology
- Местоположение издательства: United States
- Первая страница: e15080
- Последняя страница: e15080
- DOI: 10.1200/JCO.2022.40.16_suppl.e15080
- Аннотация: Hybrid organotin compound (3,5-di-tert-butyl-4-hydroxyphenylthiolate)triphenylol) is a promising candidate for antitumor drugs. The combined administration of platinum antitumor drug and an organotin compound will increase the effectiveness of therapy and reduce the general toxic effect on the body. The study was conducted on C57bl/6 mice (females, n = 48, each cohort contained 12 mice) on the Lewis epidermoid carcinoma model (subcutaneous transplantation). Cisplatin-Teva (CP) and (3,5–di–tert–butyl–4–hydroxyphenylthiolate)triphenylolol) (Me-5) were used as chemotherapeutic agents. Groups of animals were formed as follows: I (experimental) - CP at a dose of 1 mg/kg + Me-5 at a dose of 25 mg/kg; II (comparison group) - CP at a dose of 1 mg/kg; III (comparison) - Me-5 at a dose of 25 mg/kg; IV (control group) - without pharmacological substances. The compounds were administered intraperitoneally daily during 10 days. 21 days after the subinoculation of tumor cells all animals were euthanized. The antitumor effect was estimated by the percentage inhibition of tumor growth by weight. Results: The combination of the studied substances has a more pronounced antitumor effect. The percentage of reduction in the mass of the primary focus in group I was 38.1%, in group II - 20.4%, in group III - 12%. The obtained results showed that the percentage of inhibition of tumor growth by weight with a tenfold combined administration of Cisplatin-Teva and Me-5 on the Lewis epidermoid carcinoma model was significantly higher than the previously obtained result when studying the combination of Cisplatin-Teva and Me-5 with a five-fold administration which were 38.1% and 25%, respectively. The research suggests a multifactorial mechanism of action of hybrid organotin compounds.
- Добавил в систему: Шпаковский Дмитрий Борисович
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