Genetic study of predisposition to community-acquired pneumoniaстатья
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Дата последнего поиска статьи во внешних источниках: 12 июля 2017 г.
Аннотация:The study included 243 patients with acute community-acquired pneumonia and 173 healthy subjects. The following candidate loci were used to investigate genetic variability: 3 sites of CYP1A1, GSTM1, GSTTl, GSTP1, ACE gene of the rennin-angiotensin system, chemokine receptor gene CCR5. Enhanced predisposition to pneumonia was shown to be characteristic of homozygotes in deletion at the ACE locus (OR=1.8;p=0.013), carriers of normal alleles of the GSTM1 locus (0R=1.7; p=0.010), and homozygotes in allele 606T of the CYPIAl gene (OR=1.6; p=0.020).