Theoretical analysis of the predictability indices of the binary genetic testsстатья
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Дата последнего поиска статьи во внешних источниках: 12 июля 2017 г.
Авторы:
Rubanovich A.V. ,
Khromov-Borisov N.N.
Журнал:
Russian Journal of Genetics
Том:
4
Номер:
2
Год издания:
2014
Издательство:
Maik Nauka/Interperiodica Publishing
Местоположение издательства:
Russian Federation
Первая страница:
146
Последняя страница:
158
DOI:
10.1134/S2079059714020087
Аннотация:
A set of formulas for the indices of the performance and predictive ability of the binary genetic tests is presented. Their dependence on disease prevalence and the population frequency of a genetic marker is characterized. It is shown that a marker with the odds ratio OR < 2.2 has an initially low prognostic efficiency in every sense and at any frequencies of the disease and the marker. A marker can be a good classifier, when OR > 5.4, but only in case its population frequency is rather high (p M > 0.3). The formulas are presented that allow obtaining indirect estimates of the absolute and relative risk of the disease for the carrier of a marker in the case-control studies. © 2014 Pleiades Publishing, Ltd.
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