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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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The Role of Recombinant Human Cyclophilin A in the Antitumor Immune Response. Acta Naturae, V. 11, # 2(41), 2019статья
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 июня 2022 г.
- Авторы: Kalinina А.А., Silaeva Yu Yu, Kazansky D.B., Khromykh L.М.
- Журнал: Acta Naturae (англоязычная версия)
- Том: 11
- Номер: 2
- Год издания: 2019
- Издательство: Park Media Ltd
- Местоположение издательства: Moscow, Russia (Federation)
- Первая страница: 63
- Последняя страница: 67
- Аннотация: Cyclophilin A (CypA) is a multifunctional protein that exhibits an isomerase activity and exists in the intracellular and secretory forms. Secretory CypA promotes regeneration of the hematopoietic and the immune systems of an organism by stimulating stem cell migration from the bone marrow. New approaches based on CypA are currently being developed for the treatment of limb ischemia, neutralization of the side effects of Cyclosporine A (CsA) therapy, etc. However, the role of CypA in the antitumor immune response is still unexplored. In this work, we used the model experimental system of lymphoma EL-4 rejection in B10.D2(R101) mice and showed that recombinant human CypA (rhCypA) stimulates the antitumor immune response via early recruitment of granulocytes to the tumor cell localization site and rapid accumulation of effector T-killers
- Добавил в систему: Калинина Анастасия Андреевна