New Functional Criterion for Evaluation of Homologous MDR Pumps

Авторы: Nazarov Pavel A., Sorochkina Alexandra I., Karakozova Marina V.
Сборник: Alternatives to Combat Bacterial Infections
Серия: Frontiers e-book
Год издания: 2022
Издательство: Frontiers Media SA
Местоположение издательства: Lausanne, Switzerland
Первая страница: 158
Последняя страница: 162
DOI: 10.3389/978-2-88976-242-2
Аннотация: Efflux pumps simultaneously confer resistance against several antibiotic classes. In their opinion work, Nazarov et al. discuss the main efflux pump in Escherichia coli, the AcrAB-TolC system, and its role in resistance against the novel antimicrobial agent SkQ1, which interferes with bacterial bioenergetics. SkQ1 is effective against Gram-positive bacteria—it is E. coli-resistant — since AcrAB-TolC effluxes SkQ1. Regarding other Gramnegative bacteria that have the AcrAB-TolC pump, some of themlike Klebsiella pneumoniae that have an identity of 91.5% with the pump of E. coli are also resistant, while others which have lower identities are sensitive, indicating their AcrAB-TolC pump is unable to efflux SkQ1. Hence, although being phylogenetical homologs, they are not homologous in function and should be considered paralogs.
Добавил в систему: Назаров Павел Александрович

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