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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Impact of General Anesthesia and Antioxidants on Cognitive, Static and Locomotor Functions During Laparoscopic Cholecystectomyстатья
- Авторы: Moroz V.V., Dolgikh V.T., Karpitskaya S.A.
- Журнал: Revista Cubana de Medicina General Integral
- Том: 18
- Номер: 2
- Год издания: 2022
- Издательство: Centro Nacional De Informacion De Ciencias Medicas
- Местоположение издательства: Cuba
- Первая страница: 4
- Последняя страница: 11
- Аннотация: Results. Neuropsychological testing revealed postoperative cognitive dysfunction on standard therapy which included impaired attention and concentration, executive function, memory, speech, visual construc- tional skills, abstract thinking, counting, and orientation (21 points on the MoCA scale versus 28–30 points for normal). We found that the pathogenetic factors of cognitive dysfunction included insufficient antioxidant protection, decreased TNF-α and elevated interleukin-18 levels along with an increased level of C-reactive pro- tein in plasma, which manifested as activation of free-radical oxidation processes and reduced antioxidant system and performance of nonspecific resistance. Perioperative use of the combination antioxidant drug and methylethylpyridinol antioxidants reduced the frequency and severity of postoperative cognitive impairment in patients after laparoscopic cholecystectomy.
- Добавил в систему: Долгих Владимир Терентьевич