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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Immune and hormonal status disturbance in Parkinson’s diseaseтезисы доклада
- Авторы: Bocharov E.V., Kucheryanu V.G., Kryzhanovsky G.N., Bocharova O.A., Ivanova-Smolenskaya I.A., Poleschuk V.V.
- Сборник: Zhongguo Bingli Shengli Zazhi
- Том: 22
- Тезисы
- Год издания: 2006
- Первая страница: 438
- Аннотация: Parkinsonian syndrome (PS) is one of the most spreading aging desease. It is resulted in nigral dopaminergic neurons loss and damage leading to reduction of dopamine (DA) level in striatum. Immune abnormalities and hormonal status disorder are known to be involved in the pathogenesis of Parkinson's disease (PD). In this study we studed the phenotipe of circulated lymphocytes and cortisol level in peripheral blood serum in 20 PD patients compared to age-matched contlol subjects. Immune cell subpopulations were analyzed by quantifying the expression of markers using flow cytometric study. Hormone cortisol content in the blood serum was examined by radio immunoassay Patients with PD had significantly decreased the percentage of peripheral blood lymphoid cells expressing surface markers for T-cells (CD3+), T-helper cells (CD4+), B-cells (CD20+) and CD4+/CD8+ ratio. Elevated levels of cells expressing surface markers for macrophages (CD11b+), natural killers (CD16+), expressing IL-2 receptors (CD25+), Fas/APO-1 antigen (CD95+) and HLADR antigen (MHC class II) reflect pro-inflammatory immune activation. High cortisol level in PD patients correlated with ummunodepression associated with T and B cell depletion. Data obtained may indicate immune abnormalities that are possibly associated with the pathogenesis of this slowly progressive, multifactorial neurodegerative disease.
- Добавил в систему: Бочарова Ольга Алексеевна