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The Rise and Spread of the SARS-CoV-2 AY.122 Lineage in Russiaстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Klink Galya V., Safina Ksenia R., Nabieva Elena, Shvyrev Nikita, Garushyants Sofya, Alekseeva Evgeniia, Komissarov Andrey B., Danilenko Daria M., Pochtovyi Andrei A., Divisenko Elizaveta V., Vasilchenko Lyudmila A., Shidlovskaya Elena V., Kuznetsova Nadezhda A., Speranskaya Anna S., Samoilov Andrei E., Neverov Alexey D., Popova Anfisa V., Fedonin Gennady G., Akimkin Vasiliy G., Lioznov Dmitry, Gushchin Vladimir A., Shchur Vladimir, Bazykin Georgii A.
- Журнал: VIRUS EVOLUTION
- Том: 8
- Номер: 1
- Год издания: 2022
- DOI: 10.1093/ve/veac017
- Аннотация: Delta has outcompeted most preexisting variants of SARS-CoV-2, becoming the globally predominant lineage by mid-2021. Its subsequent evolution has led to emergence of multiple sublineages, most of which are well-mixed between countries. By contrast, here we show that nearly the entire Delta epidemic in Russia has probably descended from a single import event, or from multiple closely timed imports from a single poorly sampled geographic location. Indeed, over 90% of Delta samples in Russia are characterized by the nsp2:K81N+ORF7a:P45L pair of mutations which is rare outside Russia, putting them in the AY.122 sublineage. The AY.122 lineage was frequent in Russia among Delta samples from the start, and has not increased in frequency in other countries where it has been observed, suggesting that its high prevalence in Russia has probably resulted from a random founder effect rather than a transmission advantage. The apartness of the genetic composition of the Delta epidemic in Russia makes Russia somewhat unusual, although not exceptional, among other countries.
- Добавил в систему: Почтовый Андрей Андреевич