Expression of lymphotoxin beta governs immunity at two distinct levelsстатья

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Scopus, Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 сентября 2013 г.

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1. eji39191.pdf eji39191.pdf 492,2 КБ 3 августа 2013 [snedos]

[1] Expression of lymphotoxin beta governs immunity at two distinct levels / T. Junt, A. Tumanov, N. Harris et al. // European Journal of Immunology. — 2006. — Vol. 36. — P. 2061–2075. Interaction of lymphotoxin a1b2 (LTa1b2) with its receptor is key for the generation and maintenance of secondary lymphoid organ microstructure. We used mice conditionally deficient for LTb on different lymphocyte subsets to determine how the LTb-dependent lymphoid structure influences immune reactivity. All conditionally LTb-deficient mice mounted normal immune responses against vesicular stomatitis virus (VSV), and were protected against lymphocytic choriomeningitis virus (LCMV). In contrast, they exhibited reduced immune responses against non-replicating antigens. Completely LTb- deficient mice failed to retain VSV in the marginal zone and died from VSV infections, and they became virus carriers following infection with the non-cytopathic LCMV, which was correlated with defective virus replication in dendritic cells. It was ruled out that LTb expression on lymphocytes influenced their activation, homing capacity, or maturation. We therefore conclude that LTb expression influences immune reactivity at two distinct levels: (i) Expression of LTb on lymphocytes enhances the induction of immune responses against limiting amounts of antigen. (ii) Expression of LTb on non- lymphocytes governs antiviral immunity by enhancing antigen presentation on antigen- presenting cells. This prevents cytotoxic T lymphocytes exhaustion or death of the host by uncontrolled virus spread. [ DOI ]

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