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Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 14 сентября 2013 г.
- Авторы: Tumanov AV, Grivennikov SI, Kruglov AA, Shebzukhov YV, Koroleva EP, Piao Y., Cui CY, Kuprash DV, Nedospasov SA
- Журнал: Blood
- Том: 116
- Номер: 18
- Год издания: 2010
- Издательство: American Society of Hematology
- Местоположение издательства: United States
- Первая страница: 3456
- Последняя страница: 3464
- DOI: 10.1182/blood-2009-10-249177
- Аннотация: Secondary lymphoid organs provide a unique microenvironment for generation of immune responses. Using a cell type– specific conditional knockout approach, we have dissected contributions of tumor necrosis factor (TNF) produced by B cells (B-TNF) or T cells (T-TNF) to the genesis and homeostatic organization of secondary lymphoid organs. In spleen, lymph nodes and Peyer patches, the cellular source of TNF, and its molecular form (soluble versus membrane-bound) appeared distinct. In spleen, in addition to major B-TNF signal, a complementary T-TNF signal contributed to the microstructure. In contrast, B-TNF predominantly controlled the development of follicular dendritic cells and B-cell follicles in Peyer patches. In lymph nodes, coop- eration between TNF expressed by B and T cells was necessary for the maintenance of microarchitecture and for generation of an efficient humoral immune response. Unexpectedly, soluble but not membrane TNF expressed by B cells was essential for the organization of the secondary lymphoid organs. Thus, the maintenance of each type of secondary lymphoid organ is orchestrated by distinct contributions of membrane-bound and soluble TNF produced by B and T lymphocytes.
- Добавил в систему: Недоспасов Сергей Артурович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Tumanov_et_al_Blood_2010.pdf | Tumanov_et_al_Blood_2010.pdf | 1,1 МБ | 2 августа 2013 [snedos] |