Аннотация:The study of natural and resource potential of officinal plants of Ciscaucasia, i.e., plants permitted for medical use by the Ministry of Health care of Russia, has been implemented using the database developed by authors ofthe Medical-Geographical Atlas of Russia “Healing Springs and Plants.” Ciscaucasia flora of officinal plants consist of 153 species from 126 genera and 54 families.Most of officinal species grow in forest and shrub communities; some other species are cultivated in plantations. By natural features, Ciscaucasia may be divided into three parts: Western and Central with favorable conditions for plants, and the Eastern part with less suitable climatic conditions. Therefore, the regionalspecificities of officinal plants distribution result in 150 species in Western and Central parts and only 67 species in the Eastern part. Officinal plants have various pharmacological properties: antiseptic, antiinflammatory, cardiotonic, hemostatic, hypotensive, expectorant, and many others due to high concentrations of active substances. Officinal plants are used for the treatment of 14 principal classes of diseases (according to International Statistical Classification of Diseases (ICD-10)). The most frequent use is for curing diseases of the digestive system, of the circulatory system, and of the respiratory system. Large-scale stocking of medicinal raw materials results in reducing wild-growing plants populations. These processes are dangerous because the areas with nature protection status are scanty, all the while 13 officinal species are included into the Red Data Book of Russia and another 12 species—into regional Red Data books.