|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
Prediction of Number and Position of Domain Boundaries in Multi-Domain Proteins by Use of Amino Acid Sequence Aloneстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 марта 2022 г.
- Авторы: Dovidchenko Nikita, Lobanov Michail Yu, Galzitskaya Oxana
- Журнал: Current Protein and Peptide Science
- Том: 8
- Номер: 2
- Год издания: 2007
- Издательство: Bentham Science Publishers
- Местоположение издательства: Netherlands
- Первая страница: 189
- Последняя страница: 195
- DOI: 10.2174/138920307780363460
- Аннотация: Prediction of protein domain boundaries is an important step for the prediction of three-dimensional structure. The simple method PDP has been elaborated for prediction of the number and position of domain boundaries in multidomain proteins by use of amino acid sequence alone. The method uses an optimized scale based on the statistics of appearance of amino acid residues at domain boundaries. Our method demonstrates promising results in comparison to other methods that do not use homologous sequences. From the database of proteins that are targets from CASP6 (Critical Assessment of Techniques for Protein Structure Prediction) our program correctly assigned the number of domains for similar to 80% of one domain proteins and similar to 50% for two-domain proteins. Our method offers three main advantages: it is very simple, it is fast, and it uses a minimal number of parameters in comparison with other methods.
- Добавил в систему: Галзитская Оксана Валериановна