Monte Carlo simulation of dose distribution in water around 57Fe3O4 magnetite nanoparticle in the nuclear gamma resonance conditionстатья

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Дата последнего поиска статьи во внешних источниках: 5 июня 2017 г.

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[1] Monte carlo simulation of dose distribution in water around 57fe3o4 magnetite nanoparticle in the nuclear gamma resonance condition / R. Gabbasov, M. Polikarpov, V. Safronov et al. // Hyperfine Interactions. — 2016. — Vol. 237, no. 1. — P. 34. In this work was proposed a new radiotherapy enhancement method consisting of the administration of magnetic nanoparticles into the cells with further irradiation with a gamma-ray beam. As a result, adjusting the energy distribution of a gamma-ray beam and 57Fe abundance it is possible to achieve an extremely intensive electron emission because of a nuclear resonance. The produced conversion and Auger electrons can be used as an effective tool for DNA lesions production. We developed a Monte Carlo model for an electron and gamma emission by 57Fe nucleus using the Geant4 program package. The parameters of a resonant absorption were taken from Mössbauer spectra of magnetite nanoparticles synthesized for the administration into live cells. The space distribution of the radiation dose showed an increase in the dose of 2–2.5 times in the case of the natural abundance and more than 50 times in the case of the 66 % enrichment of the nanoparticles. [ DOI ]

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