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DNA Sequence recognition by bis-linked netropsin and distamycin derivativesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 января 2017 г.
- Авторы: Grokhovsky S.L., Surovaya A.N., Burckhardt G., Pismensky V.F., Chernov B.K., Zimmer C., Gursky G.V.
- Журнал: FEBS Letters
- Том: 439
- Номер: 3
- Год издания: 1998
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 346
- Последняя страница: 350
- Аннотация: We studied the interaction of cis-diammine Pt(II)- bridged bis-netropsin, cis-diammine Pt(II)-bridged bis-distamycin and oligomethylene-bridged bis-netropsin with synthetic DNA fragments containing pseudosymmetrical AT-rich nucleotide sequences and compared it with the interaction of the parent compounds netropsin and distamycin A. For fragments containing multiple blocks of (A/T)4 and (T/A)4 separated by zero, one, two and three GC-base pairs, DNase I footprinting and CD spectroscopy studies reveal that 5'-TTTTAAAA-3' is the strongest affinity binding site for cis-diammine Pt(II)-bridged bis-netropsin and bis-distamycin. They both bind less strongly to a DNA region containing the sequence 5'-AAAATTTT-3'. Netropsin, distamycin A and oligomethylene-bridged bis-netropsin exhibit far less sequence discrimination. Key words: DNA-drug interaction; Distamycin; Bis-netropsin; Bis-distamycin; d(TTTTAAAA) sequence
- Добавил в систему: Гурский Георгий Валерианович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | febs_letters_grokhosky_et_al-1998.pdf | 367,5 КБ | 16 января 2017 [GurskyGV] |
Библиографическая ссылка на публикацию в стиле
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| [1] | Dna sequence recognition by bis-linked netropsin and distamycin derivatives / S. L. Grokhovsky, A. N. Surovaya, G. Burckhardt et al. // FEBS Letters. — 1998. — Vol. 439, no. 3. — P. 346–350. We studied the interaction of cis-diammine Pt(II)- bridged bis-netropsin, cis-diammine Pt(II)-bridged bis-distamycin and oligomethylene-bridged bis-netropsin with synthetic DNA fragments containing pseudosymmetrical AT-rich nucleotide sequences and compared it with the interaction of the parent compounds netropsin and distamycin A. For fragments containing multiple blocks of (A/T)4 and (T/A)4 separated by zero, one, two and three GC-base pairs, DNase I footprinting and CD spectroscopy studies reveal that 5'-TTTTAAAA-3' is the strongest affinity binding site for cis-diammine Pt(II)-bridged bis-netropsin and bis-distamycin. They both bind less strongly to a DNA region containing the sequence 5'-AAAATTTT-3'. Netropsin, distamycin A and oligomethylene-bridged bis-netropsin exhibit far less sequence discrimination. Key words: DNA-drug interaction; Distamycin; Bis-netropsin; Bis-distamycin; d(TTTTAAAA) sequence. |