Determination of p-Methoxyphenacyl Bromide Derivatives of Alkylmethylphosphonic Acids in Urine Using Gas Chromatography with High-Resolution Mass Spectrometric Detectionстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 января 2022 г.
Аннотация:We developed a method for determining ethyl methylphosphonic, isopropyl methylphosphonic,isobutyl methylphosphonic, and pinacolyl methylphosphonic acids in human urine using gas chromatography with high-resolution mass spectrometry and preliminary derivatization with p-methoxyphenacyl bromide. All of the acids are specific hydrolysis products and biomarkers of nerve agents. Conditions of the derivatization reaction were optimized. Features and general patterns of the MS1 and MS2 spectra of derivatives acquired in electron and chemical ionization modes are revealed. The developed method achieved the limits of detection in the range from 20 to 70 ng/mL.