Аннотация:The effective charges motivated method is applied to the relation between pole and MS-scheme heavy quark masses to study high order perturbativeQCD corrections in the observable quantities proportional to the running quark masses. The non-calculated five- and six-loop perturbative QCD coefficients are estimated. This approach predicts for these terms the sign-alternating expansionin powers of number of lighter flavors n_l, while the analyzed recently infrared renormalon asymptotic expressions do not reproduce the same behavior. We emphasize that coefficients of the quark mass relation contain proportional to π^2-effects, which result from analytical continuation from the Euclidean region, where the scales of the running masses and QCD coupling constant are initially fixed, to the Minkowskian region, where the pole masses and the running QCD parameters are determined. For the t-quark the asymptotic nature of the non-resummed PT mass relation does not manifest itself at six-loops, while for the b-quark the minimal PT term appears at the probed by direct calculations four-loop level. The recent infrared renormalon based studies support theseconclusions.