Ionized Radiation-Mediated Retinoid Oxidation in the Retina and Retinal Pigment Epithelium of the Murine Eyeстатья
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 8 апреля 2022 г.
Аннотация:The present study evaluated the effects of proton and gamma-ray ionizing radiation (IR) on the mouse eye. The aim of this work was to analyze IR-mediated retinoid oxidation in the retina and retinal pigment epithelium (RPE). The findings from this analysis can be used to develop a noninvasive method for rapid assessment of the effects of IR radiation. Comparative fluorescence and chromatographic analyses of retinoids before and after IR were performed. The fluorescent properties of chloroform extracts from irradiated mouse retina and RPE exhibited an increase in fluorescence intensity in the short-wave region of the spectrum (λ <550 nm). This change is due to increased retinal and RPE retinoid oxidation and degradation products after IR exposure.Comparative analyses of the effects of exposure to IR demonstrated that the effect of proton exposure on the retina and RPE was higher than that of gamma-ray exposure. The present study revealed a new approach to assessing the level of radiation exposure in ocular tissues.