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Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eyeстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 24 ноября 2021 г.
- Авторы: Vaneev A., Tikhomirova V., Chesnokova N., Popova E., Beznos O., Kost O., Klyachko N.
- Журнал: International Journal of Molecular Sciences
- Том: 222
- Год издания: 2021
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 1
- Последняя страница: 31
- Номер статьи: 12368
- DOI: 10.3390/ijms222212368
- Аннотация: A. Vaneev, V. Tikhomirova, N. Chesnokova, E. Popova, O. Beznos, O. Kost, N. Klyachko (2021). Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye. Int. J. Mol. Sci. V. 222, Art. No. 12368. P. 1-31. (Published: 16 November 2021)https://doi.org/10.3390/ijms222212368ReviewIF 5.923 (Q1 Med)PubMed, Scopus, WoSAbstract: Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are the most prevalent drug form, especially for widely distributed anterior segment eye diseases (cataracts, glaucoma, dry eye syndrome, inflammatory diseases, etc.), because they are convenient and easy to apply by patients. However, conventional drug formulations are usually characterized by short retention time in the tear film, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Not more than 5% of the total drug dose administered in eye drops reaches the interior ocular tissues. To overcome the ocular drug delivery barriers and improve drug bioavailability, various conventional and novel drug delivery systems have been developed. Among these, nanosize carriers are the most attractive. The review is focused on the different drug carriers, such as synthetic and natural polymers, as well as inorganic carriers, with special attention to nanoparticles and nanomicelles. Studies in vitro and in vivo have demonstrated that new formulations could help to improve the bioavailability of the drugs, provide sustained drug release, enhance and prolong their therapeutic action. Promising results were obtained with drug‐loaded nanoparticles included in in situ gel.
- Добавил в систему: Клячко Наталья Львовна