|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
Mechanical Enhancement and Kinetics Regulation of Fmoc-Diphenylalanine Hydrogels by Thioflavin Tстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Tikhonova Tatiana N., Rovnyagina Nataliya N., Arnon Zohar A., Yakimov Boris P., Efremov Yuri M., Cohen-Gerassi Dana, Halperin-Sternfeld Michal, Kosheleva Nastasia V., Drachev Vladimir P., Svistunov Andrey A., Timashev Peter S., Adler-Abramovich Lihi, Shirshin Evgeny A.
- Журнал: Angewandte Chemie - International Edition
- Том: 60
- Номер: 48
- Год издания: 2021
- Издательство: John Wiley & Sons Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 25339
- Последняя страница: 25345
- DOI: 10.1002/anie.202107063
- Аннотация: The self-assembly of peptides is a key direction for fabrication of advanced materials. Novel approaches for fine tuning of macroscopic and microscopic properties of peptide self-assemblies are of a high demand for constructing biomaterials with desired properties. In this work, while studying the kinetics of the Fmoc-Diphenylalanine (Fmoc-FF) dipeptide self-assembly using the Thioflavin T (ThT) dye, we observed that the presence of ThT strongly modifies structural and mechanical properties of the Fmoc-FF hydrogel. Notably, the presence of ThT resulted in a tenfold increase of the gelation time and in the formation of short and dense fibers in the hydrogel. As a result of these morphological alteration higher thermal stability, and most important, tenfold increase of the hydrogel rigidity was achieved. Hence, ThT not only slowed the kinetics of the Fmoc-FF hydrogel formation, but also strongly enhanced its mechanical properties. In this study, we provide a detailed description of the ThT effect on the hydrogel properties and suggest the mechanisms for this phenomenon, paving the way for the novel approach to the control of the peptide hydrogels’ micro- and macroscale properties.
- Добавил в систему: Тихонова Татьяна Николаевна