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RNA-Seq Mouse Brain Regions Expression data analysis: focus on ApoE functional networkстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 ноября 2021 г.
- Авторы: Babenko V.N., Smagin D.A., Kudryavtseva N.N.
- Журнал: Journal of integrative bioinformatics
- Том: 14
- Номер: 3
- Год издания: 2017
- Издательство: Informationsmanagement in der Biotechnologie e.V. (IMBio e.V.)
- Местоположение издательства: Germany
- Номер статьи: 20170024
- DOI: 10.1515/jib-2017-0024
- Аннотация: ApoE expression status was proved to be a highly specific marker of energy metabolism rate in the brain. Along with its neighbor, Translocase of Outer Mitochondrial Membrane 40 kDa (TOMM40) which is involved in mitochondrial metabolism, the corresponding genomic region constitutes the neuroenergetic hotspot. Using RNA-Seq data from a murine model of chronic stress a significant positive expression coordination of seven neighboring genes in ApoE locus in five brain regions was observed. ApoE maintains one of the highest absolute expression values genome-wide, implying that ApoE can be the driver of the neighboring gene expression alteration observed under stressful loads. Notably, we revealed the highly statistically significant increase of ApoE expression in the hypothalamus of chronically aggressive (FDR < 0.007) and defeated (FDR < 0.001) mice compared to the control. Correlation analysis revealed a close association of ApoE and proopiomelanocortin (Pomc) gene expression profiles implying the putative neuroendocrine stress response background of ApoE expression elevation therein.
- Добавил в систему: Галямина Анна Георгиевна