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Age- related development of spike- and- wave discharges after PTZ kindling in rats with genetic absence epilepsyстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 15 декабря 2021 г.
- Авторы: Abbasova K.R., Sidorenko Darya, Tsyba Evgeniya
- Журнал: Epilepsia
- Том: 62
- Номер: S3
- Год издания: 2021
- Издательство: Blackwell Publishing Inc.
- Местоположение издательства: United Kingdom
- Номер статьи: 850
- DOI: 10.1111/epi.17079
- Аннотация: This study aimed to examine whether pentylenetetrazol- induced kindling at early postnatal age influences the development of absence epilepsy in WAG/Rij rats. 14 days old WAG/Rij rats (n=12) were treated with a subconvulsive dose of PTZ (35 mg/kg) every other day (max. 30 injections). Seizure intensity was observed, and rats were considered kindled when seizures (stage 4,5) occurred after three consecutive PTZ injections. Controls (n=12) received saline. Animals were equipped with monopolar cortical electrodes placed over the frontal cortex. EEG was recorded after 72 day every month: in pre- symptomatic period - PD73, PD90 and in post- symptomatic period - PD120, P150, PD180. SWDs were assessed by the mean duration, asymmetry index, and averaged power spectra. Experimental animals reached a stage 2– 4 but not achieved the kindling progress. The rats PD73, PD90 showed a significantly longer duration of SWDs compared to the control animals. In addition, the asymmetry index was significantly higher in this age group. Morphology analysis of SWDs revealed that discharges for experimental rats PD73, PD90 were more mature compared to control rats of the same age group. Averaged power spectrograms of SWDs revealed significant differences for rats PD73, P90 after PTZ- kindling. In rats PD120, PD150, PD180 (symptomatic period) all data was not significant. The experimental data shows that there probably is a mechanism in absence epilepsy, which is responsible for the resistance of kindling progress. Although there is, no progress of kindling in the pre- symptomatic period (PD14- PD72), at the age PD73, PD90 WAG/Rij rats showed an aggravation of absence epilepsy. We suggest that abolish the effect after PTZ- kindling at the age PD120, PD150, PD180 related maturation of SWDs, which have an antagonistic action generalization of limbic seizures during the kindling process
- Добавил в систему: Аббасова Кенул Расим кызы