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Mechanisms of cardiac muscle insensitivity to a novel acetylcholinesterase inhibitor C-547статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Abramochkin D.V., Rosenshtraukh L.V., Petrov K.A., Zobov V.V., Yagodina L.O., Nikolsky E.E.
- Журнал: Journal of Cardiovascular Pharmacology
- Том: 53
- Номер: 2
- Год издания: 2009
- Издательство: Lippincott Williams & Wilkins Ltd.
- Местоположение издательства: United States
- Первая страница: 162
- Последняя страница: 166
- DOI: 10.1097/FJC.0b013e31819867d1
- Аннотация: We compared the effects of the novel acetylcholinesterase (AChE) inhibitor C-547 on action potential configuration and sinus rhythm in the isolated right atrium preparation of rat with those of armin and neostigmine. Both armin (10(-7), 10(-6), and 10(-5) M) and neostigmine (10(-7), 10(-6), and 5 x 10(-6) M) produced a marked decrease in action potential duration and slowing of sinus rate. These effects were abolished by atropine and are attributable to the accumulation of acetylcholine in the myocardium. The novel selective AChE inhibitor C-547 (10(-9) to 10(-7) M), an alkylammonium derivative of 6-methyluracil, had no such effects. The inhibition constant of C-547 on cardiac AChE is 40-fold higher than that on extensor digitorum longus muscle AChE. These results suggest that C-547 might be employed to treat diseases such as myasthenia gravis or Alzheimer disease, without having unwanted effects on the heart.
- Добавил в систему: Абрамочкин Денис Валерьевич