Аннотация:Currently the examination of skin fibrosis is based on subjective non quantitative methods and requires
invasive procedures. Optical techniques abled to evaluate different quantitative parameters of ordered
tissues can be used to solve these problem. Measurements of endogenous fluorescence intensity, regional
tissue oxyhemoglobin saturation, and blood filling volume allowed to define the high endogenous
fluorescence intensity of porphyrin in skin fibrosis. Besides that, the decrease in oxygen intake parameters
together with the fluorescence intensity increase of collagen was determined. Consequently the optical
diagnostic techniques can become an effective method for skin fibrosis evaluation.